Rimonabant : a CB 1 receptor antagonist as a direct interactional partner for μ - and δ - opioid receptor
نویسندگان
چکیده
Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors. Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity. receptor ligand with high in vitro and in vivo agonist efficacy.
منابع مشابه
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